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Auflistung Nach Schlagwort "transfer RNA"

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    • Detection of mitochondrial transfer RNA (mt-tRNA) gene mutations in patients with idiopathic pulmonary fibrosis and sarcoidosis 

      Daniil Z., Kotsiou O.S., Grammatikopoulos A., Peletidou S., Gkika H., Malli F., Antoniou K., Vasarmidi E., Mamuris Z., Gourgoulianis K., Zifa E. (2018)
      Mitochondrial reactive oxygen species production may lead to tissue injury associated with two respiratory disorders of unknown origin which are shared by common tissue fibrosis, IPF and sarcoidosis. Sequence analysis of ...

    • Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasm 

      Bohnsack, M. T.; Regener, K.; Schwappach, B.; Saffrich, R.; Paraskeva, E.; Hartmann, E.; Görlich, D. (2002)
      Importin β-type transport receptors mediate the vast majority of transport pathways between cell nucleus and cytoplasm. We identify here the translation elongation factor 1A (eEF1A) as the predominant nuclear export substrate ...

    • Mitochondrial tRNA mutations: Clinical and functional perturbations 

      Zifa, E.; Giannouli, S.; Theotokis, P.; Stamatis, C.; Mamuris, Z.; Stathopoulos, C. (2007)
      During the last decade, there has been a progressive accumulation of reports that connect the identification of specific mitochondrial tRNA gene mutations to severe disorders in human. As a result, mitochondrial tRNA genes ...

    • New chloramphenicol derivatives from the viewpoint of anticancer and antimicrobial activity 

      Giannopoulou P.C., Missiri D.A., Kournoutou G.G., Sazakli E., Papadopoulos G.E., Papaioannou D., Dinos G.P., Athanassopoulos C.M., Kalpaxis D.L. (2019)
      Over the last years, we have been focused on chloramphenicol conjugates that combine in their structure chloramphenicol base with natural polyamines, spermine, spermidine and putrescine, and their modifications. Conjugate ...

    • Pus1p-dependent tRNA Pseudouridinylation Becomes Essential When tRNA Biogenesis Is Compromised in Yeast 

      Großhans, H.; Lecointe, F.; Grosjean, H.; Hurt, E.; Simos, G. (2001)
      Yeast Pus1p catalyzes the formation of pseudouridine (ψ) at specific sites of several tRNAs, but its function is not essential for cell viability. We show here that Pus1p becomes essential when another tRNA: pseudouridine ...

    • RNAcentral: A hub of information for non-coding RNA sequences 

      Sweeney B.A., Petrov A.I., Burkov B., Finn R.D., Bateman A., Szymanski M., Karlowski W.M., Gorodkin J., Seemann S.E., Cannone J.J., Gutell R.R., Fey P., Basu S., Kay S., Cochrane G., Billis K., Emmert D., Marygold S.J., Huntley R.P., Lovering R.C., Frankish A., Chan P.P., Lowe T.M., Bruford E., Seal R., Vandesompele J., Volders P.-J., Paraskevopoulou M., Ma L., Zhang Z., Griffiths-Jones S., Bujnicki J.M., Boccaletto P., Blake J.A., Bult C.J., Chen R., Zhao Y., Wood V., Rutherford K., Rivas E., Cole J., Laulederkind S.J.F., Shimoyama M., Gillespie M.E., Orlic-Milacic M., Kalvari I., Nawrocki E., Engel S.R., Cherry J.M., Team S., Berardini T.Z., Hatzigeorgiou A., Karagkouni D., Howe K., Davis P., Dinger M., He S., Yoshihama M., Kenmochi N., Stadler P.F., Williams K.P. (2019)
      RNAcentral is a comprehensive database of non-coding RNA (ncRNA) sequences, collating information on ncRNA sequences of all types from a broad range of organisms. We have recently added a new genome mapping pipeline that ...

    • RNase P: A promising molecular target for the development of new drugs 

      Tekos, A.; Stathopoulos, C.; Tsambaos, D.; Drainas, D. (2004)
      RNase P is an ubiquitous and essential endonuclease in tRNA biogenesis, which generates the mature 5′-termini of tRNAs. RNase P activities have been identified in all three kingdoms of life (Bacteria, Archaea, Eukarya). ...